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Breast Cancer Subtypes Vary by Ethnicity | Breast Cancer Arabia
  • Breast Cancer Subtypes Vary by Ethnicity

    NEW YORK (Reuters Health) – Breast cancer subtypes vary by ethnicity across socioeconomic status (SES) strata, according to results from the National Cancer Data Base (NCDB).
     

    “Minority women are more likely to be diagnosed with the least favorable prognosis breast cancer subtypes regardless of their socioeconomic status,” Dr. Helmneh M. Sineshaw from the American Cancer Society in Atlanta, Georgia, told Reuters Health by email.
     

    Previous studies have found different prevalences of breast cancer subtypes among women of different races and among women of different SES strata, so the contribution of each factor remains uncertain.
     

    Dr. Sineshaw and colleagues used NCDB data from 2010-2011 to estimate the odds of having each of five clinically relevant breast cancer subtypes in minority populations versus non-Hispanic whites stratified by SES. The analysis included more than 260,000 female breast cancer cases.
     

    Most cases (64.4%) were hormone receptor (HR)-positive/human epidermal growth factor receptor (HER) 2-negative. The rest were HR+/HER2+ (9.2%), HR-/HER2+ (HER2-overexpressing, 4.1%), triple negative (TN) (11.7%), or unknown (10.8%), the team reports in Breast Cancer Research and Treatment, online May 3.
     

    Compared with non-Hispanic whites, non-Hispanic blacks were 84% more likely to have TN breast cancers, and this relationship held for all SES strata.
     

    Asian/Pacific Islanders were 45% more likely than non-Hispanic whites to have HER2-overexpressing cancers, and this, too, persisted across SES strata.
     

    Hispanic women were 26% more likely than non-Hispanic whites to have HER2-overexpressing tumors.
     

    TN and HER2-overexpressing tumors were about 18 times more likely than HR+/HER2- tumors to be at grade III than grade I.
     

    “Administering diagnostic tests to identify TN breast cancer subtype in non-Hispanic black women and HER2-overexpressing breast cancer subtype in Asian/Pacific Islander women would be very important in treatment decision-making,” Dr. Sineshaw said. “Factors other than socioeconomic status that are driving these higher odds of TN or HER2-overexpressing breast cancer subtypes in minority women need to be explored.”
     

    Breast Cancer Res Treat 2014.

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